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KMID : 1123920120260030338
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 3 p.338 ~ p.343
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Oryeong-san has Different Effects on Water and Electrolyte Balance by Routes of Administration
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Ahn You-Mee
Kho Joung-hyun
Lee Jae-Yun
Kang Dae-Gill
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Abstract
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Oryeong-san which was first recorded in Shanghanrun describing the treatments of acute febrile disease is one of the frequently used oriental medicines. Oryeong-san has been prescribed for the treatment of symptoms accompanied by edema. The purpose of this study was to examine the diuretic effects of Oryeong-san by different routes of administration. Oryeong-san (100 mg/kg body weight) was administrated by three different routes in Sprague-Dawley rats: intravenous infusion, intraperitoneal injection and oral intake. Oral intake of Oryeong-san significantly increased urinary volume and excretion of Na+, Cl-, and K+ compared to vehicle-treated control group. The effects were concentration-dependent. Intravenously administrated Oryeong-san increased urinary volume and electrolyte excretion but without significance in hydrated (0.02 ml/min/rat for 90 min) anesthetized rats. Similarly, intraperitoneally injected Oryeong-san had no effects on water and urine electrolyte excretion compared with saline control group. These findings suggest that Oryeong-san has different effects on water and electrolyte balance by routes of administration.
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KEYWORD
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Oryeong-san, diuresis, administration, electrolytes balance
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